基本信息:
- 专利标题： CHIMERIC METABOTROPIC GLUTAMATE RECEPTORS AND USES THEREOF
- 专利标题（中）：CHIMERIC代谢型谷氨酸受体及其用途
- 申请号：PCT/US2004/034497 申请日：2004-10-18
- 公开(公告)号：WO2005038006A2 公开(公告)日：2005-04-28
- 发明人： GUPTA, Ashwani, K. , JACOBSON, Pamela, S. , JARVIE, Keith, R. , KRAPCHO, Karen, J. , STORJOHANN, Laura, L. , STORMANN, Thomas, M.
- 申请人： NPS PHARMACEUTICALS, INC. , GUPTA, Ashwani, K. , JACOBSON, Pamela, S. , JARVIE, Keith, R. , KRAPCHO, Karen, J. , STORJOHANN, Laura, L. , STORMANN, Thomas, M.
- 申请人地址： 420 Chipeta Way, Suite 240, Salt Lake City, UT 84108 US
- 专利权人： NPS PHARMACEUTICALS, INC.,GUPTA, Ashwani, K.,JACOBSON, Pamela, S.,JARVIE, Keith, R.,KRAPCHO, Karen, J.,STORJOHANN, Laura, L.,STORMANN, Thomas, M.
- 当前专利权人： NPS PHARMACEUTICALS, INC.,GUPTA, Ashwani, K.,JACOBSON, Pamela, S.,JARVIE, Keith, R.,KRAPCHO, Karen, J.,STORJOHANN, Laura, L.,STORMANN, Thomas, M.
- 当前专利权人地址： 420 Chipeta Way, Suite 240, Salt Lake City, UT 84108 US
- 代理机构： WARBURG, Richard, J.
- 优先权： US60/512,221 20031017; USnone 20041015
- 主分类号： C12N
- IPC分类号： C12N
摘要：
The present invention provides chimeric receptors that include an extracellular domain from a metabotropic receptor and a non-native signal peptide, e.g., a calcium receptor signal peptide. The invention also includes methods of preparing such chimeric receptors, and methods of using such receptors to identify and characterize compounds which modulate the activity of metabotropic glutamate receptors. The invention also relates to compounds and methods for modulating metabotropic glutamate receptor activity and binding to metabotropic glutamate receptors. Modulation of metabotropic glutamate receptor activity can be used for different purposes such as treating neurological disorders and diseases, inducing an analgesic effect, cognition enhancement, and inducing a muscle-relaxant effect.
摘要（中）：
本发明提供嵌合受体，其包括来自代谢代谢受体的细胞外结构域和非天然信号肽，例如钙受体信号肽。 本发明还包括制备这种嵌合受体的方法，以及使用这些受体来鉴定和表征调节代谢型谷氨酸受体活性的化合物的方法。 本发明还涉及用于调节代谢型谷氨酸受体活性并结合代谢型谷氨酸受体的化合物和方法。 代谢型谷氨酸受体活性的调节可用于治疗神经系统疾病和疾病，诱导止痛作用，认知增强和诱导肌肉松弛作用等不同目的。