基本信息:
- 专利标题： PH-TRIGGERED MICROPARTICLES
- 专利标题（中）：PH诱发微量元素
- 申请号：PCT/US2004/031173 申请日：2004-09-23
- 公开(公告)号：WO2005030174A1 公开(公告)日：2005-04-07
- 发明人： KOHANE, Daniel, S. , ANDERSON, Daniel, G. , LANGER, Robert, S. , HAINING, W., Nicolas , NADLER, Lee, M.
- 申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , DANA-FARBER CANCER INSTITUTE, INC. , THE GENERAL HOSPITAL CORPORATION , KOHANE, Daniel, S. , ANDERSON, Daniel, G. , LANGER, Robert, S. , HAINING, W., Nicolas , NADLER, Lee, M.
- 申请人地址： Five Cambridge Center, Cambridge, MA 02142-1493 US
- 专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY,DANA-FARBER CANCER INSTITUTE, INC.,THE GENERAL HOSPITAL CORPORATION,KOHANE, Daniel, S.,ANDERSON, Daniel, G.,LANGER, Robert, S.,HAINING, W., Nicolas,NADLER, Lee, M.
- 当前专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY,DANA-FARBER CANCER INSTITUTE, INC.,THE GENERAL HOSPITAL CORPORATION,KOHANE, Daniel, S.,ANDERSON, Daniel, G.,LANGER, Robert, S.,HAINING, W., Nicolas,NADLER, Lee, M.
- 当前专利权人地址： Five Cambridge Center, Cambridge, MA 02142-1493 US
- 代理机构： BAKER, C., Hunter
- 优先权： US60/505,355 20030923
- 主分类号： A61K9/16
- IPC分类号： A61K9/16
摘要：
Microparticles that are designed to release their payload when exposed to acidic conditions are provided as a vehicle for drug delivery. Any therapeutic, diagnostic, or prophylatic agent may be encapsulated in a lipid-protein-sugar or polymeric matrix including a pH triggering agent to form pH triggerable microparticles. Preferably the diameter of the pH triggered microparticles ranges from 50 nm to 10 micrometers. The matrix of the particles may be prepared using any known lipid ( e.g ., DPPQ, protein ( e.g ., albumin), or sugar ( e.g ., lactose). The matrix of the particles may also be prepared using any synthetic polymers such as polyesters. Methods of preparing and administering the particles are provided. Methods of immunization, transfection, and gene therapy are also provided by administering pH triggerable microparticles.
摘要（中）：
被设计为在暴露于酸性条件下释放其有效载荷的微粒被提供作为用于药物递送的载体。 任何治疗，诊断或预防剂可以包封在包含pH引发剂的脂质 - 蛋白质糖或聚合物基质中以形成pH可触发的微粒。 优选地，pH触发的微粒的直径范围为50nm至10微米。 颗粒的基质可以使用任何已知的脂质（例如DPPQ，蛋白质（例如白蛋白）或糖（例如乳糖））来制备。颗粒的基质也可以使用任何合成聚合物如聚酯制备。方法 提供了制备和施用颗粒的方法。通过施用pH可触发微粒也提供了免疫，转染和基因治疗的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/16 | ..块状；粒状；微珠状 |