基本信息:
- 专利标题： DIAGNOSIS AND TREATMENT OF NEPHROPATHY
- 专利标题（中）：诊断和治疗NEPHROPATHY
- 申请号：PCT/IL2004/000566 申请日：2004-06-24
- 公开(公告)号：WO2004112566A2 公开(公告)日：2004-12-29
- 发明人： MOR, Orna , FAERMAN, Alexander , FEINSTEIN, Elena
- 申请人： QUARK BIOTECH, INC. , MOR, Orna , FAERMAN, Alexander , FEINSTEIN, Elena
- 申请人地址： 6536 Kaiser Drive, Fremont, California 94555 US
- 专利权人： QUARK BIOTECH, INC.,MOR, Orna,FAERMAN, Alexander,FEINSTEIN, Elena
- 当前专利权人： QUARK BIOTECH, INC.,MOR, Orna,FAERMAN, Alexander,FEINSTEIN, Elena
- 当前专利权人地址： 6536 Kaiser Drive, Fremont, California 94555 US
- 优先权： US60/482,752 20030625
- 主分类号： A61B
- IPC分类号： A61B
摘要：
This application is directed to a method for the treatment of nephropathy or kidney fibrosis or glomerulosclerosis or chronic renal insufficiency in a subject in need of such treatment comprising administering to said subject an amount of an inhibitor of HNOEL-iso polypeptide sufficient to effect a substantial inhibition of the HNOEL-iso polypeptide so as to thereby treat the subject. This application is also directed to a process of obtaining a compound which inhibits human HNOEL-iso polypeptide This application is also directed to use of a compound identified by that process in the preparation of a medicament for therapy of disease, in particular nephropathy, and to diagnostic aspects related to HNOEL-iso polypeptide.
摘要（中）：
本申请涉及用于治疗需要这种治疗的受试者的肾病或肾纤维化或肾小球硬化或慢性肾功能不全的方法，包括向所述受试者施用足以实现基本抑制的量的HNOEL-iso多肽抑制剂 的HNOEL-iso多肽，从而治疗受试者。 本申请还涉及获得抑制人HNOEL-iso多肽的化合物的方法。本申请还涉及通过该方法鉴定的化合物在制备用于治疗疾病，特别是肾病的药物中的用途，以及 与HNOEL-iso多肽相关的诊断方面。
公开/授权文献:
- WO2004112566A3 DIAGNOSIS AND TREATMENT OF NEPHROPATHY 公开/授权日：2004-12-29