基本信息:
- 专利标题： METHOD AND SYSTEM FOR INTRAVESICULAR DELIVERY OF THERAPEUTIC AGENTS
- 专利标题（中）：用于治疗药物的急性输送的方法和系统
- 申请号：PCT/US0333448 申请日：2003-10-22
- 公开(公告)号：WO2004037318A3 公开(公告)日：2004-08-26
- 发明人： FRIEDMAN CRAIG D , COSTANTINO PETER D , DATTA ARINDAM , TINKELENBERG ARTHUR H
- 申请人： BIOMERIX CORP , FRIEDMAN CRAIG D , COSTANTINO PETER D , DATTA ARINDAM , TINKELENBERG ARTHUR H
- 专利权人： BIOMERIX CORP,FRIEDMAN CRAIG D,COSTANTINO PETER D,DATTA ARINDAM,TINKELENBERG ARTHUR H
- 当前专利权人： BIOMERIX CORP,FRIEDMAN CRAIG D,COSTANTINO PETER D,DATTA ARINDAM,TINKELENBERG ARTHUR H
- 优先权： US42018002 2002-10-22
- 主分类号： A61F2/00
- IPC分类号： A61F2/00 ; A61F2/04 ; A61F2/36 ; A61F6/06 ; A61K9/00 ; A61K9/22 ; A61K9/70 ; A61L27/14 ; A61L27/34 ; A61L27/54 ; A61L27/56 ; A61L31/10 ; A61L31/14 ; A61L31/16 ; A61M20060101 ; A61M31/00
摘要：
A therapeutic agent delivery implant (42) for implantation into a patient's body comprises a resilient or flexible, at least partially hydrophobic reticulated elastomeric support scaffold; and a hydrophilic coating arranged on said scaffold, wherein said coating contains one or more therapeutic agents for release within the patient. Optionally the coating can contain microspheres or enzymes. In a preferred embodiment, the scaffold comprises a hydrophobic polyurethane, the coating comprises a hydrophilic polyurethane, and the implant has a hemispherical, bullet, football, cylindrical, spherical, or irregular shape. The implant can be delivered through a rigid or flexible delivery instrument that deploys the implant at a desirable site, whereby the implant expands to a size and shape substantially similar to its size and shape before insertion.
摘要（中）：
用于植入患者体内的治疗剂递送植入物（42）包括弹性或柔性的至少部分疏水的网状弹性支撑支架; 和布置在所述支架上的亲水性涂层，其中所述涂层含有用于在患者体内释放的一种或多种治疗剂。 任选地，涂层可以含有微球体或酶。 在优选的实施方案中，支架包含疏水性聚氨酯，该涂层包含亲水性聚氨酯，并且该植入物具有半球形，子弹，足球，圆柱形，球形或不规则形状。 植入物可以通过将植入物部署在期望的位置处的刚性或柔性递送仪器来输送，由此植入物在插入之前扩展成与其尺寸和形状基本相似的尺寸和形状。