基本信息:
- 专利标题: SALMONELLA VIRULENCE FACTORS AND USES THEREOF
- 专利标题(中):SALMONELLA VIRULENCE因子及其用途
- 申请号:PCT/US2002/035039 申请日:2002-11-01
- 公开(公告)号:WO2003038116A2 公开(公告)日:2003-05-08
- 发明人: AUSUBEL, Frederick, M. , ABALLAY, Alejandro , DRENKARD, Eliana , MCCORMICK, Beth, A.
- 申请人: THE GENERAL HOSPITAL CORPORATION , AUSUBEL, Frederick, M. , ABALLAY, Alejandro , DRENKARD, Eliana , MCCORMICK, Beth, A.
- 申请人地址: 55 Fruit Street, Boston, MA 02114 US
- 专利权人: THE GENERAL HOSPITAL CORPORATION,AUSUBEL, Frederick, M.,ABALLAY, Alejandro,DRENKARD, Eliana,MCCORMICK, Beth, A.
- 当前专利权人: THE GENERAL HOSPITAL CORPORATION,AUSUBEL, Frederick, M.,ABALLAY, Alejandro,DRENKARD, Eliana,MCCORMICK, Beth, A.
- 当前专利权人地址: 55 Fruit Street, Boston, MA 02114 US
- 代理机构: DECAMP, James, D.
- 优先权: US60/334,761 20011101
- 主分类号: C12Q
- IPC分类号: C12Q
摘要:
The invention features nucleic acid molecules encoding microbial virulence factors (such as gmhA ) and methods of using such gene (and their proteins) as targets to identify anti-pathogenic agents. The invention also features a method of identifying a compound that inhibits the pathogenicity of an effector protein in a nematode, the method involving the steps of: (a) providing a nematode expressing an effector protein; (b) contacting the nematode with a test compound; and (c) determining whether the test compound inhibits the pathogenicity of the effector polypeptide in the nematode.
摘要(中):
本发明的特征在于编码微生物毒力因子(例如,gmhA)的核酸分子和使用该基因(及其蛋白质)作为靶标的方法来鉴定抗病原体。 本发明还涉及鉴定抑制线虫中效应蛋白的致病性的化合物的方法,所述方法包括以下步骤:(a)提供表达效应蛋白的线虫; (b)使线虫与测试化合物接触; 和(c)确定测试化合物是否抑制线虫中效应多肽的致病性。