基本信息:
- 专利标题： SYNTHESIS AND INTERMEDIATES
- 专利标题（中）：合成与中间体
- 申请号：PCT/EP2002/007308 申请日：2002-07-02
- 公开(公告)号：WO2003004455A2 公开(公告)日：2003-01-16
- 发明人： ÖHRLEIN, Reinhold , BAISCH, Gabriele , KIRNER, Hans, Jörg , BIENEWALD, Frank , BURKHARDT, Stephan , STUDER, Martin
- 申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , ÖHRLEIN, Reinhold , BAISCH, Gabriele , KIRNER, Hans, Jörg , BIENEWALD, Frank , BURKHARDT, Stephan , STUDER, Martin
- 申请人地址： Klybeckstrasse 141, CH-4057 Basel CH
- 专利权人： CIBA SPECIALTY CHEMICALS HOLDING INC.,ÖHRLEIN, Reinhold,BAISCH, Gabriele,KIRNER, Hans, Jörg,BIENEWALD, Frank,BURKHARDT, Stephan,STUDER, Martin
- 当前专利权人： CIBA SPECIALTY CHEMICALS HOLDING INC.,ÖHRLEIN, Reinhold,BAISCH, Gabriele,KIRNER, Hans, Jörg,BIENEWALD, Frank,BURKHARDT, Stephan,STUDER, Martin
- 当前专利权人地址： Klybeckstrasse 141, CH-4057 Basel CH
- 代理机构： CIBA SPECIALTY CHEMICALS HOLDING INC.
- 优先权： EP01810670.8 20010706
- 主分类号： C07C227/32
- IPC分类号： C07C227/32
摘要：
The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein R a ' and R c ' are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and R b is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein R a ' and R c ' are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and R b is a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation.
摘要（中）：
本发明涉及制备适于制备他汀类衍生物的中间体的合成方法，特别是式（Ⅵ）中间体的合成方法，其中R a'和R c'各自独立地为氢或羟基 保护基团或一起是桥接羟基保护基团，Rb是羧基保护基团，该方法通过式（XVI）的中间体的转化来进行，其中R a'和R c'各自独立地为氢 或羟基保护基，R *和R **各自独立地为氢或酰胺保护基，Rb为羧基保护基; 哪些方法进行进一步的中间体及其制备方法。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C227/00 | 含有连在同一碳架上的氨基和羧基的化合物的制备 |
| --------C07C227/30 | .制备旋光异构体 |
| ----------C07C227/32 | ..通过立体有择合成 |