发明申请
WO2002083714A3 METHOD AND SYSTEM FOR OPTIMIZING MULTI-EPITOPE NUCLEIC ACID CONSTRUCTS AND PEPTIDES ENCODED THEREBY
审中-公开
基本信息:
- 专利标题： METHOD AND SYSTEM FOR OPTIMIZING MULTI-EPITOPE NUCLEIC ACID CONSTRUCTS AND PEPTIDES ENCODED THEREBY
- 申请号：PCT/US2002/009877 申请日：2002-03-28
- 公开(公告)号：WO2002083714A3 公开(公告)日：2002-10-24
- 发明人： SETTE, Alessandro , CHESNUT, Robert , LIVINGSTON, Brian, D. , BAKER, Denise, Marie , NEWMAN, Mark, J. , BROWN, David, H.
- 申请人： EPIMMUNE INC. , SETTE, Alessandro , CHESNUT, Robert , LIVINGSTON, Brian, D. , BAKER, Denise, Marie , NEWMAN, Mark, J. , BROWN, David, H.
- 申请人地址： 5820 Nancy Ridge Road, Suite 100, San Diego, CA 92121 US
- 专利权人： EPIMMUNE INC.,SETTE, Alessandro,CHESNUT, Robert,LIVINGSTON, Brian, D.,BAKER, Denise, Marie,NEWMAN, Mark, J.,BROWN, David, H.
- 当前专利权人： EPIMMUNE INC.,SETTE, Alessandro,CHESNUT, Robert,LIVINGSTON, Brian, D.,BAKER, Denise, Marie,NEWMAN, Mark, J.,BROWN, David, H.
- 当前专利权人地址： 5820 Nancy Ridge Road, Suite 100, San Diego, CA 92121 US
- 代理机构： STEFFE, Eric, K.
- 优先权： US60/284,221 20010416; US09/894,018 20010627
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of spacer nucleic acid at the junctions of the multi-epitope constructs encoding a plurality of CTL and/or HTL eoutioe oeotudes so as to minimize the number of junciontal epitopes and provide vaccines with increased immunogenicity.