发明申请
WO0220558A2 METHOD FOR BINDING, IN SOLUTION, A PEPTIDE AND A LIPOPHILIC VECTOR AND USES THEREOF
审中-公开
基本信息:
- 专利标题： METHOD FOR BINDING, IN SOLUTION, A PEPTIDE AND A LIPOPHILIC VECTOR AND USES THEREOF
- 专利标题（中）：用于结合，解决方案，肽和脂质载体的方法及其用途
- 申请号：PCT/FR0102787 申请日：2001-09-07
- 公开(公告)号：WO0220558A2 公开(公告)日：2002-03-14
- 发明人： BONNET DOMINIQUE , BOUREL LINE , MELNYK OLEG
- 申请人： PASTEUR INSTITUT , CENTRE NAT RECH SCIENT , BONNET DOMINIQUE , BOUREL LINE , MELNYK OLEG
- 专利权人： PASTEUR INSTITUT,CENTRE NAT RECH SCIENT,BONNET DOMINIQUE,BOUREL LINE,MELNYK OLEG
- 当前专利权人： PASTEUR INSTITUT,CENTRE NAT RECH SCIENT,BONNET DOMINIQUE,BOUREL LINE,MELNYK OLEG
- 优先权： FR0011451 2000-09-08
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/12 ; A61K47/48 ; C07C235/74 ; C07D263/04 ; C07D498/04 ; C07K1/02 ; C07K1/107 ; C07K7/06 ; C07K14/57
摘要：
The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, said coupling comprising a step which consists in producing a hydrazone bond between said peptide compound and said lipophilic vector. The invention also concerns lipophilic vectors for use in said method, lipopeptides obtained by said method, uses of said lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.
摘要（中）：
本发明涉及在溶液中结合至少一种肽组合物和至少一种具有醛官能团的亲脂性载体的方法，所述偶联包括在所述肽化合物和所述亲脂性载体之间产生腙键的步骤。 本发明还涉及用于所述方法的亲脂性载体，通过所述方法获得的脂肽，所述脂肽用于细胞筛选的用途，以及本发明的应用，特别是用于制备肽类活性成分（例如激素 或神经肽）通过生理屏障如细胞膜。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |