发明申请
WO1996028465A1 HETEROCYCLECARBONYL AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS
审中-公开
基本信息:
- 专利标题： HETEROCYCLECARBONYL AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS
- 专利标题（中）：间苯二酚氨基酸羟基乙酰胺氨基磺酸替代蛋白酶抑制剂
- 申请号：PCT/US1996002683 申请日：1996-03-07
- 公开(公告)号：WO1996028465A1 公开(公告)日：1996-09-19
- 发明人： G.D. SEARLE & CO.
- 申请人： G.D. SEARLE & CO. , GETMAN, Daniel, P. , DECRESCENZO, Gary, A. , FRESKOS, John, N. , VAZQUEZ, Michael, L. , SIKORSKI, James, A. , DEVADAS, Balekudru , NAGARAJAN, Srinivasan , BROWN, David, L. , McDONALD, Joseph, J.
- 专利权人： G.D. SEARLE & CO.,GETMAN, Daniel, P.,DECRESCENZO, Gary, A.,FRESKOS, John, N.,VAZQUEZ, Michael, L.,SIKORSKI, James, A.,DEVADAS, Balekudru,NAGARAJAN, Srinivasan,BROWN, David, L.,McDONALD, Joseph, J.
- 当前专利权人： G.D. SEARLE & CO.,GETMAN, Daniel, P.,DECRESCENZO, Gary, A.,FRESKOS, John, N.,VAZQUEZ, Michael, L.,SIKORSKI, James, A.,DEVADAS, Balekudru,NAGARAJAN, Srinivasan,BROWN, David, L.,McDONALD, Joseph, J.
- 优先权： US8/402,419 19950310; US8/474,117 19950607
- 主分类号： C07K05/078
- IPC分类号： C07K05/078
摘要：
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds of formula (I) are effective as retroviral protease inhibitors, and in particular as inhibitor of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and the treatment of a retroviral infection.
摘要（中）：
选择的式（I）的杂环羰基氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。 本发明涉及这种逆转录病毒蛋白酶抑制剂，更具体地涉及所选择的新化合物，用于抑制逆转录病毒蛋白酶如人类免疫缺陷病毒（HIV）蛋白酶的组合物和方法，预防性地预防逆转录病毒感染或逆转录病毒的扩散，以及 治疗逆转录病毒感染。