发明申请
WO9318005A3 PROCESSES FOR PRODUCING 2-HALO-NICOTINIC ACID DERIVATIVES AND PRECURSORS THERETO
审中-公开
基本信息:
- 专利标题： PROCESSES FOR PRODUCING 2-HALO-NICOTINIC ACID DERIVATIVES AND PRECURSORS THERETO
- 专利标题（中）：生产2-羟基丁酸酸衍生物及其前体的方法
- 申请号：PCT/US9302117 申请日：1993-03-08
- 公开(公告)号：WO9318005A3 公开(公告)日：1993-10-28
- 发明人： ZHANG TONY Y , SCRIVEN ERIC F V
- 申请人： REILLY IND INC
- 专利权人： REILLY IND INC
- 当前专利权人： REILLY IND INC
- 优先权： US84794092 1992-03-06
- 主分类号： C07B61/00
- IPC分类号： C07B61/00 ; C07C253/30 ; C07C255/21 ; C07D213/73 ; C07D213/79 ; C07D213/80 ; C07D213/82
摘要：
Disclosed are preferred processes for the preparation of 2-halo-nicotinic acid derivatives of formula (IV) by cyclocondensation of a 4-halo-4-cyanocarbonyl compound of formula (III) wherein X is Cl or Br; Y is a carbonyl group and R?1, R2 and R3¿ are each, independently, H, Cl, Br or an organic radical. Further preferred aspects include the preparation of the above-noted 4-halo-4-cyanocarbonyl compound via Michael addition of a 2-halonitrile with an α,β-unsaturated aldehyde or ketone, and the preparation of the 2-halonitrile by redistribution of halogen between a 2,2-dihalonitrile and a parent nitrile.