基本信息:
- 专利标题： METHOD AND COMPOSITION FOR TREATING THROMBOSIS
- 专利标题（中）：治疗血栓形成的方法和组合
- 申请号：PCT/US1991002356 申请日：1991-04-05
- 公开(公告)号：WO1991015515A1 公开(公告)日：1991-10-17
- 发明人： LA JOLLA CANCER RESEARCH FOUNDATION
- 申请人： LA JOLLA CANCER RESEARCH FOUNDATION , PIERSCHBACHER, Michael, D. , LUKEMAN, David, S. , CHENG, Soan , CRAIG, William, S. , TSCHOPP, Juerg, F.
- 专利权人： LA JOLLA CANCER RESEARCH FOUNDATION,PIERSCHBACHER, Michael, D.,LUKEMAN, David, S.,CHENG, Soan,CRAIG, William, S.,TSCHOPP, Juerg, F.
- 当前专利权人： LA JOLLA CANCER RESEARCH FOUNDATION,PIERSCHBACHER, Michael, D.,LUKEMAN, David, S.,CHENG, Soan,CRAIG, William, S.,TSCHOPP, Juerg, F.
- 优先权： US506,444 19900406
- 主分类号： C07K15/00
- IPC分类号： C07K15/00
摘要：
The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and contain hydrophobic moieties adjacent to the carboxy terminus of the RGD sequence. Peptides of this nature are also provided which contain in addition to the hydrophobic moiety an adjacent positively charged moiety. Such peptides have a high affinity for the receptor IIb/IIIa and a low affinity for the fibronectin and vitronectin receptors. Such peptides can be administered in a suitable physiologically acceptable carrier to therapeutically treat thrombosis.
摘要（中）：
本发明提供抑制血小板聚集而不引起延长出血时间的环肽。 本发明提供含RGD或KGD的肽，其环化并含有与RGD序列的羧基末端相邻的疏水部分。 还提供了这种性质的肽，除了疏水部分外还含有相邻带正电的部分。 这样的肽对受体IIb / IIIa具有高亲和力，对纤连蛋白和玻连蛋白受体的亲和力低。 这样的肽可以在合适的生理学上可接受的载体中施用以治疗性治疗血栓形成。