基本信息:
- 专利标题： CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE
- 申请号：US17045952 申请日：2019-04-08
- 公开(公告)号：US20210163456A1 公开(公告)日：2021-06-03
- 发明人： Gregg F. KEANEY , John WANG , Baudouin GERARD , Kenzo ARAI , Xiang LIU , Guo Zhu ZHENG , Kazunobu KIRA , Lisa A. MARCAURELLE , Marta NEVALAINEN , Ming-Hong HAO , Morgan Welzel O'SHEA , Parcharee TIVITMAHAISOON , Sudeep PRAJAPATI , Touping LUO , Nicholas C. GEARHART , Jason T. LOWE , Yoshihiko KOTAKE , Satoshi NAGAO , Regina Mikie KANADA SONOBE , Masayuki MIYANO , Norio MURAI , Andrew COOK , Shelby ELLERY , Atsushi ENDO , James PALACINO , Dominic REYNOLDS
- 申请人： EISAI R&D MANAGEMENT CO., LTD.
- 申请人地址： JP Tokyo
- 专利权人： EISAI R&D MANAGEMENT CO., LTD.
- 当前专利权人： EISAI R&D MANAGEMENT CO., LTD.
- 当前专利权人地址： JP Tokyo
- 国际申请： PCT/US2019/026313 WO 20190408
- 主分类号： C07D407/06
- IPC分类号： C07D407/06 ; C07D405/14 ; A61P35/00 ; C07D313/00 ; C07D491/107 ; C07D487/08 ; C07D487/10 ; A61K45/06 ; C07D405/12 ; C07D417/12 ; C07D413/12
摘要：
The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
公开/授权文献:
- US11926619B2 Certain pladienolide compounds and methods of use 公开/授权日：2024-03-12
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D407/00 | 杂环化合物，含两个或更多个杂环，至少有1个环有氧原子作为仅有的杂环原子，C07D405/00组不包含的 |
| --------C07D407/02 | .含有两个杂环 |
| ----------C07D407/06 | ..被仅含脂族碳原子的碳链连接的 |