发明申请
US20200270264A1 MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO
审中-公开
![MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO](/abs-image/US/2020/08/27/US20200270264A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO
- 申请号:US16872812 申请日:2020-05-12
- 公开(公告)号:US20200270264A1 公开(公告)日:2020-08-27
- 发明人: Thuy-Anh Tran , Quyen-Quyen Do , Brett Ullman , Anthony C. Blackburn , Maiko Nagura
- 申请人: Arena Pharmaceuticals, Inc.
- 主分类号: C07D491/107
- IPC分类号: C07D491/107 ; A61P9/04 ; A61P9/10
摘要:
The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure; cardiac performance in heart failure; mortality, reinfarction, and/or hospitalization in connection with heart failure; acute heart failure; acute decompensated heart failure; congestive heart failure; severe congestive heart failure; organ damage associated with heart failure (e.g., kidney damage or failure, heart valve problems, heart rhythm problems, and/or liver damage); heart failure due to left ventricular dysfunction; heart failure with normal ejection fraction; cardiovascular mortality following myocardial infarction; cardiovascular mortality in patients with left ventricular failure or left ventricular dysfunction; left ventricular failure; left ventricular dysfunction; class II heart failure using the New York Heart Association (NYHA) classification system; class III heart failure using the New York Heart Association (NYHA) classification system; class IV heart failure using the New York Heart Association (NYHA) classification system; LVEF
公开/授权文献:
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D491/00 | 杂环化合物,在稠环系中含有1个或多个有氧原子作为仅有的杂环原子的环,且含有1个或多个有氮原子作为仅有的杂环原子的环,不包含在C07D451/00至C07D459/00、C07D463/00、C07D477/00或C07D489/00组中 |
--------C07D491/02 | .在稠环系中含有两个杂环 |
----------C07D491/10 | ..螺稠合系 |
------------C07D491/107 | ...在含氧环中只有1个氧原子作为杂环原子 |