基本信息:
- 专利标题： NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION
- 申请号：US15933098 申请日：2018-03-22
- 公开(公告)号：US20180230092A1 公开(公告)日：2018-08-16
- 发明人： XIAODONG XU , JU-TAO GUO , TONG XIAO , YANMING DU , TIMOTHY BLOCK , SIMON DAVID PETER BAUGH , HONG YE
- 申请人： DREXEL UNIVERSITY , BARUCH S. BLUMBERG INSTITUTE , ARBUTUS BIOPHARMA, INC.
- 主分类号： C07C311/16
- IPC分类号： C07C311/16 ; C07D319/16 ; C07D309/04 ; C07D305/08 ; C07D295/32 ; C07D295/30 ; C07D295/26 ; C07D277/52 ; C07D277/46 ; C07D263/58 ; C07D263/50 ; C07D263/48 ; C07D261/14 ; C07D239/26 ; C07D231/42 ; C07D231/40 ; C07D217/24 ; C07D215/42 ; C07D215/38 ; C07D213/76 ; C07D213/75 ; C07D213/40 ; C07D211/96 ; C07D205/04 ; C07D203/26 ; C07C317/14 ; C07C311/48 ; C07C311/20 ; C07C311/19 ; C07C311/18 ; C07C311/17 ; C07C309/89 ; C07C233/66 ; C07D319/18
摘要：
The present invention is directed toward novel compounds and novel methods of use of said compounds of the formula (I), useful as nucleocapsid assembly inhibitors for the treatment of viruses, especially but not exclusively, including pregenomic RNA encapsidation inhibitors of HBV for the treatment of Hepatitis B virus (HBV) infection and related conditions. including hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein A, R1, R2, R3, R4, R5, R6, R7, and R8 are defined herein.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C311/00 | 磺酰胺，即磺基的单键氧原子被不属于硝基或亚硝基的氮原子取代的化合物 |
| --------C07C311/15 | .磺酰胺基的硫原子连接在六元芳环碳原子上的磺酰胺 |
| ----------C07C311/16 | ..有至少1个磺酰胺基的氮原子连接在氢原子或非环碳原子上 |