基本信息:
- 专利标题： PLASMODIUM LIVER STAGE ANTIGENS
- 专利标题（中）：PLASMODIUM肝脏阶段抗原
- 申请号：US12722439 申请日：2010-03-11
- 公开(公告)号：US20100166794A1 公开(公告)日：2010-07-01
- 发明人： Patrick Duffy , Stefan H.I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
- 申请人： Patrick Duffy , Stefan H.I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
- 申请人地址： US WA Seattle US MD Fort Detrick US PA Philadelphia
- 专利权人： SEATTLE BIOMEDICAL RESEARCH INSTITUTE,The USA, as Represented by the Secretary of the Army,on Behalf of the Walter Reed,Philadelphia Health & Education Corporation, d/b/a Drexel University College of Medicine "DUCOM"
- 当前专利权人： SEATTLE BIOMEDICAL RESEARCH INSTITUTE,The USA, as Represented by the Secretary of the Army,on Behalf of the Walter Reed,Philadelphia Health & Education Corporation, d/b/a Drexel University College of Medicine "DUCOM"
- 当前专利权人地址： US WA Seattle US MD Fort Detrick US PA Philadelphia
- 主分类号： A61K39/002
- IPC分类号： A61K39/002 ; C07K14/445 ; C07H21/04 ; A61P33/06
摘要：
The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.
摘要（中）：
本发明提供了分离的肝阶段疟原虫多肽，其包含选自SEQ ID NO：1-48的氨基酸序列及其免疫原性衍生物。 本发明还提供编码本发明的肝阶段疟原虫多肽的分离的核酸分子，包含本发明的一种或多种肝阶段疟原虫多肽的组合物，诱导针对肝阶段的疟原虫多肽的免疫应答的方法，以及治疗和诊断方法 肝阶段疟疾。
公开/授权文献:
- US08318183B2 Plasmodium liver stage antigens 公开/授权日：2012-11-27
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/002 | .原生动物抗原 |