基本信息:
- 专利标题： Industrially Useful Microorganism
- 专利标题（中）：工业上有用的微生物
- 申请号：US11720020 申请日：2005-11-25
- 公开(公告)号：US20080009041A1 公开(公告)日：2008-01-10
- 发明人： Hiroshi Mizoguchi , Kiyotaka Hara , Hideo Mori
- 申请人： Hiroshi Mizoguchi , Kiyotaka Hara , Hideo Mori
- 优先权： JP2004-341706 20041126; JP2005-203965 20050713
- 国际申请： PCT/JP05/21691 WO 20051125
- 主分类号： C12P1/04
- IPC分类号： C12P1/04 ; C12N1/20 ; C12P19/00 ; C12P21/00
摘要：
According to the present invention, the E. coli mutant strain having chromosomal DNA that is at least 470 kbp shorter than that of a wild-type E. coli strain exhibits such a property that the number of the cells after a certain period of culture is greater than a wild-type strain. Thus, by culturing the mutant strain in a medium so as to generate and accumulate a useful substance in the culture, a useful substance such as proteins, peptides, amino acids, nucleic acids, vitamins, saccharides, organic acids, and lipids can be efficiently produced.
摘要（中）：
根据本发明，具有比野生型大肠杆菌菌株短至少470kbp的染色体DNA的大肠杆菌突变菌株表现出这样的性质，即在一定培养时间后的细胞数为 大于野生型菌株。 因此，通过在培养基中培养突变菌株以在培养物中产生和积累有用物质，可以有效地使用蛋白质，肽，氨基酸，核酸，维生素，糖类，有机酸和脂质等物质 生产。