发明申请
US20070049565A1 Combination of cell necrosis inhibitor and lithium for treating neuronal death or neurological dysfunction
审中-公开
基本信息:
- 专利标题： Combination of cell necrosis inhibitor and lithium for treating neuronal death or neurological dysfunction
- 专利标题（中）：细胞坏死抑制剂和锂的组合用于治疗神经元死亡或神经功能障碍
- 申请号：US11503379 申请日：2006-08-11
- 公开(公告)号：US20070049565A1 公开(公告)日：2007-03-01
- 发明人： Byoung Gwag , Young Lee , Jin Shin , Sung Cho , Jae Noh , Jae Cho , Ki Kim , Hyang Lim , Jae Lee , Han Byun
- 申请人： Byoung Gwag , Young Lee , Jin Shin , Sung Cho , Jae Noh , Jae Cho , Ki Kim , Hyang Lim , Jae Lee , Han Byun
- 申请人地址： KR Suwon-si
- 专利权人： Neurotech Pharmaceuticals Co., Ltd.
- 当前专利权人： Neurotech Pharmaceuticals Co., Ltd.
- 当前专利权人地址： KR Suwon-si
- 优先权： KR10-2005-0078028 20050824
- 主分类号： A61K31/60
- IPC分类号： A61K31/60 ; A61K31/195 ; A61K31/24 ; A61K31/137
摘要：
The present invention relates to a combination of cell necrosis inhibitor and lithium, process for the preparation of the combination, pharmaceutical formulation containing the combination and use of the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The combination of the present invention shows a synergic effect and thus is useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.
摘要（中）：
本发明涉及细胞坏死抑制剂和锂的组合，制备该组合的方法，含有组合的药物制剂以及通过伴随或连续施用组合使用以改善神经元死亡或神经功能障碍的治疗。 本发明的组合显示出协同效应，因此可用于治疗诸如肌萎缩性侧索硬化（ALS，Lou Gehrig's disease），阿尔茨海默病，帕金森病，亨廷顿病，中风，创伤性脑损伤或脊髓损伤等神经疾病 ; 并用于治疗眼部疾病如青光眼，糖尿病性视网膜病变或黄斑变性。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/60 | .水杨酸；其衍生物 |