基本信息:
- 专利标题： Microfluidic protein crystallography techniques
- 专利标题（中）：微流体蛋白晶体学技术
- 申请号：US10810350 申请日：2004-03-26
- 公开(公告)号：US20050062196A1 公开(公告)日：2005-03-24
- 发明人： Carl Hansen , Stephen Quake , James Berger
- 申请人： Carl Hansen , Stephen Quake , James Berger
- 申请人地址： US CA Pasadena 92115 US CA Oakland
- 专利权人： California Institute of Technology,The Regents of the University of California
- 当前专利权人： California Institute of Technology,The Regents of the University of California
- 当前专利权人地址： US CA Pasadena 92115 US CA Oakland
- 主分类号： B29C33/40
- IPC分类号： B29C33/40 ; C12Q20060101
摘要：
The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.
摘要（中）：
本发明涉及促进结晶物质如蛋白质生长和分析的微流体装置和方法。 根据一个实施例，晶体生长结构由具有大得多体积的相邻阱的可渗透膜分离。 该孔可以被配置成包含具有与晶体生长中使用的溶剂和结晶剂相似的特性和浓度的流体，并且通过膜的扩散稳定了该过程。 或者，孔可以被配置为包含具有计算以影响结晶过程的同一性的流体。 根据另一个实施方案，所述孔可以被配置为容纳诸如冷冻保护剂的材料，其可用于在形成后保护结晶材料。
公开/授权文献:
- US07217321B2 Microfluidic protein crystallography techniques 公开/授权日：2007-05-15
IPC结构图谱:
| B | 作业；运输 |
| --B29 | 塑料的加工；一般处于塑性状态物质的加工 |
| ----B29C | 塑料的成型或连接；塑性状态物质的一般成型；已成型产品的后处理，如修整 |
| ------B29C33/00 | 模型或型芯；其零件或所用的附件 |
| --------B29C33/12 | .有插入的定位镶嵌件的装置，例如定位标牌的装置 |
| ----------B29C33/40 | ..塑料，如泡沫塑料、橡胶 |