基本信息:
- 专利标题： 캡슐화 세포의 동결-건조 방법, 동결 건조된 캡슐화 세포, 동결 건조된 캡슐화 세포를 함유하는 조성물, 및 상기 세포 및 조성물의 용도
- 专利标题（英）：- A METHOD OF FREEZE-DRYING ENCAPSULATED CELLS FREEZE-DRIED ENCAPSULATED CELLS COMPOSITIONS CONTAINING FREEZE-DRIED ENCAPSULATED CELLS AND USES OF SUCH CELLS AND COMPOSITIONS
- 申请号：KR1020167002913 申请日：2014-07-02
- 公开(公告)号：KR102250588B1 公开(公告)日：2021-05-12
- 发明人： 살몬스,브라이언 , 댄저필드,존에이. , 귄츠버그,왈터에이치.
- 申请人： 오스트리아노바 싱가포르 피티이 리미티드
- 申请人地址： ** Biopolis Way, #**-*** Centros, Singapore ******, Singapore
- 专利权人： 오스트리아노바 싱가포르 피티이 리미티드
- 当前专利权人： 오스트리아노바 싱가포르 피티이 리미티드
- 当前专利权人地址： ** Biopolis Way, #**-*** Centros, Singapore ******, Singapore
- 代理人： 특허법인다나
- 优先权： EP131746810 2013-07-02
- 国际申请： PCT/EP2014/064087 2014-07-02
- 国际公布： WO2015000972 2015-01-08
- 主分类号： A01N1/02
- IPC分类号： A01N1/02 ; A23L1/30 ; A23L1/00 ; A61K9/48 ; A61K8/11 ; A61K8/98 ; A61K35/20 ; A61Q19/00
摘要：
본발명은일반적으로동결-건조캡슐화세포의제조방법에관한것이다. 또한, 본발명은상기방법에의해수득된동결건조세포뿐만아니라상기동결건조캡슐화세포를포함하는조성물, 및상기세포의다양한용도, 예를들면, 약학적, 기능성식품(nutraceutical), 식품첨가제, 또는화장료첨가제로서의용도를제공한다. 또한, 본발명은탈지유, 글리세롤, 및탄수화물을함유하는신규한조성물을제공하며, 예를들면, 캡슐화세포의동결-건조를위해사용될수 있다.
摘要（英）：
The disclosure provides a method of freeze-drying encapsulated cells, the method comprising at least two consecutive incubation steps, wherein the encapsulated cells are incubated in each incubation step in an incubation solution containing cryoprotectant over a suitable period of time, wherein the concentration of cryoprotectant in the incubation solution is increased with each subsequent incubation step. The disclosure also provides freeze dried cells that are obtained by this method as well as various uses of these cells as pharmaceutical, food additive or additive in cosmetics. The disclosure also provides a composition that contains skim milk, glycerol and a carbohydrate.