基本信息:
- 专利标题： 신규한 벤조디아제핀 유도체
- 专利标题（英）：Novel benzodiazepine derivatives
- 专利标题（中）：新的苯二甲酸衍生物
- 申请号：KR1020117020390 申请日：2010-02-04
- 公开(公告)号：KR1020110120308A 公开(公告)日：2011-11-03
- 发明人： 리,웨이 , 피쉬킨,나단,엘리엇 , 자오,로버트,용신 , 밀러,마이클,루이스 , 체리라비,브이.,제이.
- 申请人： 이뮤노젠 아이엔씨
- 申请人地址： *** Winter Street, Waltham, Massachusetts *****-****, U.S.A.
- 专利权人： 이뮤노젠 아이엔씨
- 当前专利权人： 이뮤노젠 아이엔씨
- 当前专利权人地址： *** Winter Street, Waltham, Massachusetts *****-****, U.S.A.
- 代理人： 양영준; 김영
- 优先权： US61/150,201 2009-02-05
- 国际申请： PCT/US2010/023150 2010-02-04
- 国际公布： WO2010091150 2010-08-12
- 主分类号： C07D519/04
- IPC分类号： C07D519/04 ; C07K5/103 ; A61K31/5517
The invention of the formula The novel relates to benzodiazepine derivatives, more particularly to a diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is a cyclic By having antiproliferative activity ( I) and (II) the novel benzodiazepine or diazepine ring (B) is fused with a heterocyclic ring (C) of, where the heterocyclic ring, to a compound of formula (III) monocyclic. The present invention provides a dimer of such cytotoxic compounds. The invention also provides a conjugate of a monomer and dimer. The invention also use of the compound or conjugate of the present invention provides compositions and methods useful for inhibiting abnormal cell growth in a mammal or a proliferative disorder treated. The invention also relates to a method of using a mammalian cells, or associated pathological conditions in vitro, in drilling, and the compound or conjugate for the in vivo diagnosis or treatment.
公开/授权文献:
- KR101835033B1 신규한 벤조디아제핀 유도체 公开/授权日：2018-03-08
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D519/00 | 杂环化合物，含有1个以上的由两个或更多个相关杂环组成的环系，杂环间彼此稠合，或与1个共同碳环系稠合，不包含在C07D453/00或C07D455/00组内 |
| --------C07D519/04 | .二聚吲哚生物碱，例如，长春碱 |