发明公开
KR1020110053467A 술폰산에스테르 구조를 도입한 페닐기를 치환기로서 갖는 신규 1,2,3,4-테트라히드로퀴녹살린 유도체를 포함하는 글루코코르티코이드 수용체 작용제
无效 - Withdrawn
基本信息:
- 专利标题： 술폰산에스테르 구조를 도입한 페닐기를 치환기로서 갖는 신규 1,2,3,4-테트라히드로퀴녹살린 유도체를 포함하는 글루코코르티코이드 수용체 작용제
- 专利标题（英）：Glucocorticoid receptor agonist comprising novel 1,2,3,4-tetrahydroquinoxaline derivatives containing phenyl group having sulfonic acid ester structure introduced therein as substituent
- 专利标题（中）：含有作为替代物引入的磺酸酯结构的苯基的新的1,2,3,4-四氢喹啉衍生物的GLUCOCORTICOID受体激动剂
- 申请号：KR1020117007506 申请日：2009-09-11
- 公开(公告)号：KR1020110053467A 公开(公告)日：2011-05-23
- 发明人： 가토마사토모 , 다카이미와 , 마츠야마다카히로 , 구로세다츠지 , 하기와라유미 , 오키겐지 , 마츠다마모루 , 모리도시유키
- 申请人： 산텐 세이야꾸 가부시키가이샤
- 申请人地址： *-**, Shimoshinjo *-chome, Higashiyodogawa-ku, Osaka-shi Osaka-fu, Japan
- 专利权人： 산텐 세이야꾸 가부시키가이샤
- 当前专利权人： 산텐 세이야꾸 가부시키가이샤
- 当前专利权人地址： *-**, Shimoshinjo *-chome, Higashiyodogawa-ku, Osaka-shi Osaka-fu, Japan
- 代理人： 강승옥; 김성기
- 优先权： JPJP-P-2008-234105 2008-09-12
- 国际申请： PCT/JP2009/065888 2009-09-11
- 国际公布： WO2010029986 2010-03-18
- 主分类号： C07D241/44
- IPC分类号： C07D241/44 ; C07D241/42 ; A61K31/498 ; A61P29/00
(R
1 은 하기 화학식 2a, 3a, 4a 또는 5a를 나타내고, R
2 는 치환기를 가져도 좋은 저급 알킬기, 치환기를 가져도 좋은 저급 시클로알킬기 등을 나타내며, R
3 은 저급 알킬기를 나타내고, R
4 , R
5 , R
6
또는 R
7 은 할로겐 원자, 치환기를 가져도 좋은 저급 알킬기, 히드록시기, 치환기를 가져도 좋은 저급 알콕시기 등을 나타내며, m, n, p 또는 q는 0, 1 또는 2를 나타낸다:
The present invention seeks to find a new pharmacological action of novel 1,2,3,4-tetrahydro-quinoxaline derivative having a phenyl group to introduce a sulfonic acid ester structure as a substituent. A compound or a salt thereof represented by the general formula (1) is useful as a glucocorticoid receptor agonist. In particular, it is useful as a therapeutic agent for glucocorticoid receptor function, such as steroids I disease is believed to be effective, such as inflammatory bone-joint disorders, it is not inflammatory diseases (anterior or after regards inflammatory diseases).
(R
1 is to represent the general formula 2a, 3a, 4a or represents 5a, R
2 is a good lower alkyl group which may have a substituent, and may have a substituent, a lower cycloalkyl group, R
3 denotes a lower alkyl group, R
4, R
5, R
6
Or R
7 is a which may have a halogen atom, an optionally substituted lower alkyl group get the good, a hydroxy group, the substituent represents a good such as a lower alkoxy group, m, n, p or q represents 0, 1 or 2:
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D241/00 | 杂环化合物，含1,4-二嗪环或氢化1,4-二嗪环 |
| --------C07D241/02 | .不与其他环稠合 |
| ----------C07D241/38 | ..只有氢或碳原子直接连在环氮原子上 |
| ------------C07D241/40 | ...苯并吡嗪 |
| --------------C07D241/44 | ....有杂原子或有以3个键连杂原子、其中最多以1个键连卤素的碳原子，例如酯基或腈基，直接连在杂环的碳原子上 |