基本信息:
- 专利标题： 새로운 에이사이클릭 뉴클레오사이드 포스포네이트유도체, 그의 염 및 합성 방법
- 专利标题（英）：Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same
- 专利标题（中）：新型ACYCLIC核苷酸衍生物及其合成方法及其合成方法
- 申请号：KR1020020003051 申请日：2002-01-18
- 公开(公告)号：KR1020020062216A 公开(公告)日：2002-07-25
- 发明人： 최종류 , 김정민 , 노기윤 , 조동규 , 임재홍 , 황재택 , 조우영 , 장현숙 , 이장호 , 김태균 , 조승주 , 김경원 , 최태생 , 김청미 , 김용주
- 申请人： 주식회사 엘지생명과학
- 申请人地址： 서울특별시 종로구 새문안로 ** (신문로*가)
- 专利权人： 주식회사 엘지생명과학
- 当前专利权人： 주식회사 엘지생명과학
- 当前专利权人地址： 서울특별시 종로구 새문안로 ** (신문로*가)
- 代理人： 최규팔
- 优先权： KR1020010003087 2001-01-19
- 主分类号： C07F9/38
- IPC分类号： C07F9/38
摘要：
PURPOSE: Provided are a novel Acyclic nucleoside phosphonate derivative which is useful as an anti-viral agent(especially hepatitis B virus), its pharmaceutically acceptable salt and stereochemical isomer, and their synthesis method. CONSTITUTION: Acyclic nucleoside phosphonate derivative is represented by the formula(1), wherein R1, R2, R3, R4, R5, R7, R8, Y and Q are as described in the description. It comprises natural base, such as adenine, guanine, uracil, thymine or their derivative. It is manufactured by: (a) reacting a compound of the formula(2) with a compound of the formula(3) of QH; (b) reacting a compound of the formula(9) with a compound of the formula(3) of QH to obtain a compound of the formula(10) then hydrolyzing the compound of the formula(10) in the presence of Lewis acid to obtain a compound of the formula(1a); or (c) introducing R4 and R5 to the compound of the formula(1a) to obtain a compound of the formula(1b) then converting it.
摘要（中）：
目的：提供一种可用作抗病毒剂（特别是乙型肝炎病毒），其药学上可接受的盐和立体化学异构体的新型非环型核苷膦酸酯衍生物及其合成方法。 构成：无环核苷膦酸酯衍生物由式（1）表示，其中R 1，R 2，R 3，R 4，R 5，R 7，R 8，Y和Q如说明书所述。 它包括天然碱，如腺嘌呤，鸟嘌呤，尿嘧啶，胸腺嘧啶或其衍生物。 通过以下方法制备：（a）使式（2）的化合物与QH的式（3）的化合物反应; （b）使式（9）的化合物与QH的式（3）的化合物反应，得到式（10）的化合物，然后在路易斯酸的存在下将式（10）的化合物水解成 得到式（1a）化合物; 或（c）将R4和R5引入式（1a）化合物，得到式（1b）化合物，然后转化。
公开/授权文献:
- KR100441638B1 새로운 에이사이클릭 뉴클레오사이드 포스포네이트유도체, 그의 염 및 합성 방법 公开/授权日：2004-07-23
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07F | 含除碳、氢、卤素、氧、氮、硫、硒或碲以外的其他元素的无环，碳环或杂环化合物 |
| ------C07F9/00 | 含周期表第Ⅴ族元素的化合物 |
| --------C07F9/02 | .磷化合物 |
| ----------C07F9/06 | ..无P—C键的 |
| ------------C07F9/38 | ...膦酸；硫代膦酸 |