The present invention relates to self-assembly of recombinant proteins and their use comprising a targeting peptide. Recombinant self-assembling protein comprising a targeting peptide in accordance with the present invention for delivering a desired drug without the use of an auxiliary agent such as a chemical binder or stabilizers because they do not require additional targeting given process in a target tissue or target cells it is possible, and thus can be used for photothermal therapy, drug delivery or imaging.
In particular, while having the additional passivation process without the need for a directional or target grant process, the targeting according to the present invention are gold nanoparticles with a uniform high-density gold bonded to the protein surface can be produced protein nanoparticles fusions. Gold in accordance with the present invention the protein nanoparticles fusions so targeting also excellent showed a structural stability to the change of variation, and the concentration of the pH compared to the conventional gold nanoparticles, the promotion of innovative utilization in the photothermal therapy of gold nanoparticles It can bring.