基本信息:
- 专利标题： 組換え発現ベクター及び当該ベクターを封入した脂質膜構造体
- 专利标题（英）：JPWO2017090763A1 - Lipid membrane structure enclosing a recombinant expression vector and the vector
- 申请号：JP2016085098 申请日：2016-11-28
- 公开(公告)号：JPWO2017090763A1 公开(公告)日：2018-09-13
- 发明人： 原島 秀吉 , 山田 勇磨 , 石川 卓哉 , 秋田 英万
- 申请人： 国立大学法人北海道大学
- 申请人地址： 北海道札幌市北区北8条西5丁目
- 专利权人： 国立大学法人北海道大学
- 当前专利权人： 国立大学法人北海道大学
- 当前专利权人地址： 北海道札幌市北区北8条西5丁目
- 代理人： 特許業務法人IPアシスト特許事務所
- 优先权： JP2015230498 2015-11-26
- 主分类号： C12N15/88
- IPC分类号： C12N15/88 ; A61P43/00 ; A61K48/00 ; A61K35/76 ; C12N15/85
Disclosed is a purpose of efficiently expressing a desired protein in the mitochondria, and can suppress the undesired expression of a protein of interest in cell organelles other than mitochondria, providing a new expression vector to. The invention relates to a promoter sequence which shows transcriptional activity in the cell nucleus of animal cells, and a coding region encoding a target protein, the coding region containing one or more TGA as codon corresponding to tryptophan wherein a under the control of a promoter sequence, a recombinant expression vector for expressing a target protein in the mitochondria of animal cells, as well as lipid membrane structure enclosing the vector. By using the expression vectors of the present invention can be utilized as a more efficient, and can be selectively drives the expression of target proteins, a more safe and effective excellent medicaments for mitochondrial diseases treated in the mitochondria . .The