PROBLEM TO BE SOLVED: To make an enzyme and an enteric substance to arrive at an intestine without being exposed to a gastric juice. SOLUTION: An oil liquid 2 containing CoQ 10 of enteric substance is encapsulated with a gelatin coating film 3 to form a seamless nucleus 1, and an enzyme-containing coating film 4 is disposed on the surface of the seamless nucleus 1 to form an enzyme-compounded granule 5. The enzyme-compounded granules 5 are charged and sealed in a hard capsule 6, and the whole surface of the capsule is coated with zein 7 to form an enzyme-compounded food 8. When the enzyme-compounded food 8 is drunk, the enzyme-compounded food 8 arrives at the intestine through a stomach without being dissolved in a gastric juice due to the existence of the coating layer of the zein 7. The coating layer of the zein 7, and the hard capsule 6 are sequentially collapsed in the intestine, and the enzyme compounded in the enzyme-containing coating films 4 of the enzyme-compounded granules 5 are released in the intestine. The gelatin coating films 3 of the seamless nuclei 1 exposed by the collapse of the coating films 4 are collapsed to release the oil liquid 2 containing the CoQ 10 in the intestine. COPYRIGHT: (C)2008,JPO&INPIT