发明专利
JP2008092952A Method for preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms
审中-公开
基本信息:
- 专利标题： Method for preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms
- 专利标题（中）：含24个环状体的含有CYCLODEPSIPEPTIPES的取代芳香酸乳酸的方法
- 申请号：JP2007271390 申请日：2007-10-18
- 公开(公告)号：JP2008092952A 公开(公告)日：2008-04-24
- 发明人： JESCHKE PETER , BONSE GERHARD , THIELKING GERHARD , ETZEL WINFRIED , HARDER ACHIM , MENCKE NORBERT , KLEINKAUF HORST , ZOCHER RAINER , IINUMA KATSUHARU , MIYAMOTO KOICHI
- 申请人： Bayer Ag , バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft
- 专利权人： Bayer Ag,バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft
- 当前专利权人： Bayer Ag,バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ
- 优先权： DE19545639 1995-12-07
- 主分类号： C12P21/02
- IPC分类号： C12P21/02 ; C07D273/00 ; C07K11/00 ; C12P1/00 ; C12P17/14 ; C12R1/645
摘要：
PROBLEM TO BE SOLVED: To provide an effective method for preparation of substituted aryl lactic acid containing cyclodepsipeptides.
SOLUTION: The invention relates to the new method for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms, comprising addition of 4-nitrophnyl lactate to a main culture liquid of Mycelia sterilia, a fungal strain of the Agonomycetales class under an asceptic condition, continuing fermentation and extracting and purifying the culture, or adding substrates such as leucine, lactic acid, ATP, S-adenosyl-L-methionine, 4-nitrophenyl lactate, etc., to the enzymatic preparation isolated from the fungal strain to carry out an in vitro reaction.
COPYRIGHT: (C)2008,JPO&INPIT
摘要（中）：
SOLUTION: The invention relates to the new method for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms, comprising addition of 4-nitrophnyl lactate to a main culture liquid of Mycelia sterilia, a fungal strain of the Agonomycetales class under an asceptic condition, continuing fermentation and extracting and purifying the culture, or adding substrates such as leucine, lactic acid, ATP, S-adenosyl-L-methionine, 4-nitrophenyl lactate, etc., to the enzymatic preparation isolated from the fungal strain to carry out an in vitro reaction.
COPYRIGHT: (C)2008,JPO&INPIT
待解决的问题：提供一种制备含取代芳基乳酸的环糊精肽的有效方法。 解决方案：本发明涉及制备具有24个环原子的取代芳基乳酸含环糊精肽的新方法，该方法包括向主体培养液中加入4-硝基丙酸乳酸菌，该菌株是菌丝体灭菌菌的一种真菌菌株 在无菌条件下，继续发酵并提取和纯化培养物，或将底物如亮氨酸，乳酸，ATP，S-腺苷-L-甲硫氨酸，4-硝基苯基乳酸等添加到从真菌中分离的酶制剂 菌株进行体外反应。 版权所有（C）2008，JPO＆INPIT
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C12 | 生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程 |
| ----C12P | 发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体 |
| ------C12P21/00 | 肽或蛋白质的制备 |
| --------C12P21/02 | .有两个或更多个氨基酸的已知序列，如谷胱苷肽 |