基本信息:
- 专利标题： Ion channel inhibitory compounds, pharmaceutical formulations and uses
- 申请号：IL25919918 申请日：2018-05-08
- 公开(公告)号：IL259199A 公开(公告)日：2022-03-01
- 发明人： XINMIN XIE , FRANK KAYSER
- 申请人： AFASCI INC , XINMIN XIE , FRANK KAYSER
- 专利权人： AFASCI INC,XINMIN XIE,FRANK KAYSER
- 当前专利权人： AFASCI INC,XINMIN XIE,FRANK KAYSER
- 优先权： US201562254564 2015-11-12
- 主分类号： A61K31/4747
- IPC分类号： A61K31/4747 ; A61K31/4453 ; A61P25/00 ; A61P25/04 ; A61P25/08 ; A61P25/14 ; A61P29/00 ; A61P43/00
摘要：
The present invention is directed towards new chemical entities which primarily inhibit the human T-type calcium channels and differentially modulate other key ion channels to control cell excitability, and abnormal neuronal activity particularly involved in the development and maintenance of persistent or chronic pain, and/or neurological disorders. These novel compounds are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which these ion channels are involved. The invention is also directed towards pharmaceutical formulations comprising these compounds and the uses of these compounds.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/47 | ....喹啉；异喹啉 |
| ----------------A61K31/4747 | .....螺环稠合的 |