发明公开
EP4371568A3 LIPASE DEGRADATION RESISTANT SURFACTANTS FOR USE IN LARGE MOLECULE THERAPEUTIC FORMULATIONS
审中-实审
基本信息:
- 专利标题： LIPASE DEGRADATION RESISTANT SURFACTANTS FOR USE IN LARGE MOLECULE THERAPEUTIC FORMULATIONS
- 申请号：EP24167511.5 申请日：2019-08-22
- 公开(公告)号：EP4371568A3 公开(公告)日：2024-09-11
- 发明人： LABRENZ, Steven , STAHL, Patrick
- 申请人： Janssen Biotech, Inc.
- 申请人地址： US Horsham, PA 19044 800/850 Ridgeview Drive
- 专利权人： Janssen Biotech, Inc.
- 当前专利权人： Janssen Biotech, Inc.
- 当前专利权人地址： US Horsham, PA 19044 800/850 Ridgeview Drive
- 代理机构： Carpmaels & Ransford LLP
- 优先权： US 1862721884P 2018.08.23
- 分案原申请号： 19852009.0 2019.08.22
- 主分类号： A61K9/08
- IPC分类号： A61K9/08 ; A61K39/395 ; A61K39/44 ; A61K47/10 ; A61K47/34 ; A61K31/25 ; A61K38/46
摘要：
The present invention is directed to pharmaceutical formulations of therapeutic proteins that comprise one or more polyethoxylated fatty alcohol (PFA) surfactants that are resistant to lipase mediated degradation. The present invention is also directed to methods of reducing aggregate and/or particulate formation in pharmaceutical formulations of therapeutic proteins and methods of maintaining a stable surfactant level in pharmaceutical formulations of therapeutic proteins.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/08 | .溶液 |