基本信息:
- 专利标题： PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA
- 申请号：EP23179901.6 申请日：2011-08-31
- 公开(公告)号：EP4226941A1 公开(公告)日：2023-08-16
- 发明人： GEALL, Andrew , VERMA, Ayush
- 申请人： GlaxoSmithKline Biologicals S.A.
- 申请人地址： BE 1330 Rixensart Rue de l'Institut, 89
- 当前专利权人： GLAXOSMITHKLINE BIOLOGICALS SA
- 当前专利权人地址： GLAXOSMITHKLINE BIOLOGICALS SA
- 代理机构： West, Heloise
- 优先权： US37882610 P 20100831
- 主分类号： A61K39/39
- IPC分类号： A61K39/39 ; A61K9/127
摘要：
Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1kDa and 3kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is between 1kDa and 3kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
公开/授权文献:
- EP4226941B1 PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA 公开/授权日：2024-10-23
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/39 | .以免疫刺激添加剂，例如化学佐剂为特征的 |