
基本信息:
- 专利标题: NASAL ADMINISTRATION
- 申请号:EP19173055.5 申请日:2006-01-19
- 公开(公告)号:EP3546000A1 公开(公告)日:2019-10-02
- 发明人: DJUPESLAND, Per, Gisle , HAFNER, Roderick, Peter
- 申请人: Optinose AS
- 申请人地址: Oslo Innovation Center Gaustadalléen 21 0349 Oslo NO
- 专利权人: Optinose AS
- 当前专利权人: Optinose AS
- 当前专利权人地址: Oslo Innovation Center Gaustadalléen 21 0349 Oslo NO
- 代理机构: Boden, Keith McMurray
- 主分类号: A61M15/08
- IPC分类号: A61M15/08
摘要:
A delivery device for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal airway of a subject and comprising an outlet unit which includes a nozzle for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle; wherein the delivery device is configured such that at least 30 % of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance. Sumatriptan or its pharmaceutically-acceptable derivatives or analogues for use in the treatment of migraine.