基本信息:
- 专利标题： A METHOD OF PREDICTING PHENOTYPIC INSTABILITY IN A CELL
- 申请号：EP15718799.8 申请日：2015-04-02
- 公开(公告)号：EP3126833B1 公开(公告)日：2018-06-13
- 发明人： THOMPSON, Ben , JAMES, David , CLIFFORD, Jerry
- 申请人： Valitacell Limited
- 申请人地址： NIBRT Fosters Ave. Mountain Merrion Blackrock, Co. Dublin IE
- 专利权人： Valitacell Limited
- 当前专利权人： VALITACELL LIMITED
- 当前专利权人地址： VALITACELL LIMITED
- 代理机构： Carmody, Mark
- 优先权： EP14163519 20140404
- 国际公布： WO2015150551 20151008
- 主分类号： G01N33/50
- IPC分类号： G01N33/50
摘要：
A method for predicting the phenotypic stability of a cell line comprises the steps of culturing the cell line over an assay period, and generating an environmental response fingerprint for the cell line at a plurality of different time points over the assay period, wherein each environmental response fingerprint is generated by determining the environmental response of the cells in the presence of each of a plurality of chemical cell stressors. The plurality of environmental response fingerprints are compared to detect change in the environmental response fingerprint over the assay period. The level of change in the environmental response fingerprint over the assay period is indicative of the level of predicted phenotypic instability in the cell line. The environmental response may be growth response, productivity response, or another detectable environmental response.
公开/授权文献:
- EP3126833A1 A METHOD OF PREDICTING PHENOTYPIC INSTABILITY IN A CELL 公开/授权日：2017-02-08