发明公开
EP2763985A1 MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS
有权
基本信息:
- 专利标题： MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS
- 专利标题（中）：{（4-（4-吗啉代二氢 - 噻吩并[3,4-d]嘧啶-2-基）芳基}脲或氨基甲酸酯衍生物ALS mTOR抑制剂
- 申请号：EP12769098.0 申请日：2012-10-05
- 公开(公告)号：EP2763985A1 公开(公告)日：2014-08-13
- 发明人： LYNCH, Rosemary , CANSFIELD, Andrew David , HARDY, Daniel Paul , FEUTRILL, John Thomas , ADREGO, Rita , ELLARD, Katie , LADDUWAHETTY, Tammy
- 申请人： Cellzome Limited
- 申请人地址： 980 Great West Road Brentford, Middlesex TW8 9GS GB
- 专利权人： Cellzome Limited
- 当前专利权人： Cellzome Limited
- 当前专利权人地址： 980 Great West Road Brentford, Middlesex TW8 9GS GB
- 代理机构： Shore, Andrew David
- 优先权： EP11184358 20111007; US201261649995P 20120522
- 国际公布： WO2013050508 20130411
- 主分类号： C07D417/02
- IPC分类号： C07D417/02 ; A61K31/519
摘要：
The invention relates to compounds of formula (I) wherein m, o, R
a , R
b , R
1 and T
1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
a , R
b , R
1 and T
1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D417/00 | 杂环化合物，含两个或更多个杂环、至少有1个环有氮原子和硫原子作为仅有的杂环原子，C07D415/00组不包含的 |
| --------C07D417/02 | .含有两个杂环 |