发明公开
EP2737923A2 ELECTRO-MICRONEEDLE INTEGRATED BODY FOR IN-SITU CUTANEOUS GENE TRANSFER AND METHOD OF MANUFACTURING SAME
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基本信息:
- 专利标题： ELECTRO-MICRONEEDLE INTEGRATED BODY FOR IN-SITU CUTANEOUS GENE TRANSFER AND METHOD OF MANUFACTURING SAME
- 专利标题（中）：电极与集成微针用于引入遗传物质的和用于它们的制备方法
- 申请号：EP12818195.5 申请日：2012-07-19
- 公开(公告)号：EP2737923A2 公开(公告)日：2014-06-04
- 发明人： JUNG, Hyungil , LEE, Kwang , JEONG, Do Hyeon , KIM, Jung Dong
- 申请人： Raphas Co., Ltd. , Industry-Academic Cooperation Foundation, Yonsei University
- 申请人地址： 319 DMC High-Tech Industrial Center 1580 bunji Sangam-dong Mapo-gu Seoul 121-912 KR
- 专利权人： Raphas Co., Ltd.,Industry-Academic Cooperation Foundation, Yonsei University
- 当前专利权人： RAPHAS CO., LTD.
- 当前专利权人地址： RAPHAS CO., LTD.
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： KR20110074250 20110726
- 国际公布： WO2013015563 20130131
- 主分类号： A61M37/00
- IPC分类号： A61M37/00 ; A61K48/00 ; A61M5/158
摘要：
Provided is an electro-microneedle integrated body in which a dissolving microneedle and an electrode for electroporation are integrated into one, which enables a focused and efficient intracutaneous gene release for percutaneous gene delivery and intracellular gene delivery occurring in one in-situ treatment site The electro-microneedle integrated body according to the present invention includes an electrode for electroporation which is contacted with skin of a human body to apply an electric field pulse, including a base part and a plurality of electrode parts protruding from the base part, and a microneedle adhered to each electrode part and inserted into the skin of a human body, including a biocompatible and biodegradable viscous material and a genetic material, wherein the microneedle degrades within the skin, and the electric field pulse is applied through the electrode for electroporation in a site in which the microneedle is inserted.
摘要（中）：
提供的是一种电子微针集成体，其中的溶解微针和电极，用于电穿孔被集成为一体，这使得经皮基因递送和细胞内基因递送的聚焦和高效的皮内基因释放在一个原位治疗部位的电发生的 - 微针集成体雅丁到本发明包括在电极用于电穿孔的所有其与人体的皮肤接触，以适用于电场脉冲，包括基部和从该基部部分突出电极部分多个，以及微针附着 到各电极部和插入到人体，包括生物相容的和可生物降解的粘性材料和遗传物质，在皮肤内worin微针降低，并且电场脉冲通过电极施加用于电穿孔在一个部位的皮肤 其中微针插入。