基本信息:
- 专利标题： CHIMERIC INFLUENZA VIRUS-LIKE PARTICLES COMPRISING HEMAGGLUTININ
- 专利标题（中）：包含血凝素的嵌合流感病毒样颗粒
- 申请号：EP10791119.0 申请日：2010-06-25
- 公开(公告)号：EP2445928B1 公开(公告)日：2018-03-28
- 发明人： COUTURE, Manon , DARGIS,Michele , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe , D'AOUST, Marc-Andre
- 申请人： Medicago Inc.
- 申请人地址： 1020 route de l'Eglise Suite 600 Québec, Québec G1V 3V9 CA
- 专利权人： Medicago Inc.
- 当前专利权人： Medicago Inc.
- 当前专利权人地址： 1020 route de l'Eglise Suite 600 Québec, Québec G1V 3V9 CA
- 代理机构： Lusuardi, Werther
- 优先权： US220161P 20090624
- 国际公布： WO2010148511 20101229
- 主分类号： C07K14/11
- IPC分类号： C07K14/11 ; A01H5/00 ; A61K39/145 ; A61P31/16 ; C12N15/44 ; C12N15/82 ; C12N7/00 ; C12N7/01 ; C07K19/00
摘要：
A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K14/00 | 具有多于20个氨基酸的肽；促胃液素；生长激素释放抑制因子；促黑激素；其衍生物 |
| --------C07K14/005 | .来自病毒 |
| ----------C07K14/01 | ..DNA病毒 |
| ------------C07K14/11 | ...正粘病毒科，例如流感病毒 |