基本信息:
- 专利标题： Process for producing thiazole derivative
- 专利标题（中）：Verfahren zur Herstellung von Thiazolderivaten
- 申请号：EP10013476.6 申请日：2004-11-12
- 公开(公告)号：EP2266991A2 公开(公告)日：2010-12-29
- 发明人： Nagasawa, Hiroshi , Sato, Koji , Yagi, Tsutomu , Kitani, Yasuo
- 申请人： Daiichi Sankyo Company, Limited
- 申请人地址： 3-5-1, Nihombashi-honcho Chuo-ku Tokyo 103-8426 JP
- 专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人： DAIICHI SANKYO COMPANY, LIMITED
- 当前专利权人地址： DAIICHI SANKYO COMPANY, LIMITED
- 代理机构： Hartz, Nikolai
- 优先权： JP2003382382 20031112; JP2003382383 20031112; JP2003382384 20031112
- 主分类号： C07D513/04
- IPC分类号： C07D513/04 ; C07B41/08 ; C07B39/00 ; C07B43/04
摘要：
A process for producing a compound of formula (5) or a salt thereof:
[F18]
wherein the process is characterized by comprising reacting a compound of formula (1) or a salt thereof:
[F15]
with sulfur powder and cyanamide in the presence of a secondary amine, to thereby obtain a compound of formula (2) or a salt thereof:
[F16]
and reacting the obtained compound or a salt thereof hydrobromic acid and alkali metal nitrite, to thereby obtain a compound of formula (3) or a salt thereof:
F17]
and reacting the obtained compound or a salt thereof with alkyllithium and carbon dioxide.
摘要（中）：
[F18]
wherein the process is characterized by comprising reacting a compound of formula (1) or a salt thereof:
[F15]
with sulfur powder and cyanamide in the presence of a secondary amine, to thereby obtain a compound of formula (2) or a salt thereof:
[F16]
and reacting the obtained compound or a salt thereof hydrobromic acid and alkali metal nitrite, to thereby obtain a compound of formula (3) or a salt thereof:
F17]
and reacting the obtained compound or a salt thereof with alkyllithium and carbon dioxide.
一种制备式（5）化合物或其盐的方法：[F18]其中该方法的特征在于包括使式（1）化合物或其盐：[F15]与硫磺粉末和氨腈反应， 的仲胺，从而得到式（2）的化合物或其盐：[F16]并使所得化合物或其氢溴酸和碱金属亚硝酸盐的盐反应，由此得到式（3）的化合物或 其盐：F17]并使所得化合物或其盐与烷基锂和二氧化碳反应。
公开/授权文献:
- EP2266991B1 Process for producing thiazole derivative 公开/授权日：2018-07-11
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D513/00 | 杂环化合物，在稠环系中至少有1个杂环具有氮原子和硫原子作为仅有的杂环原子，不包含在C07D463/00、C07D477/00或C07D499/00至C07D507/00组中 |
| --------C07D513/02 | .稠环系中含有两个杂环 |
| ----------C07D513/04 | ..邻位稠合系 |