基本信息:
- 专利标题： TRICYCLIC AMIDE COMPOUND
- 专利标题（中）：三环酰胺
- 申请号：EP08792457.7 申请日：2008-08-14
- 公开(公告)号：EP2189443A1 公开(公告)日：2010-05-26
- 发明人： AMANO, Yohei , NOGUCHI, Masayuki , SHUDO, Koichi
- 申请人： Research Foundation Itsuu Laboratory
- 申请人地址： 28-10, Tamagawa 2-chome, Setagaya-ku Tokyo 158-0094 JP
- 专利权人： Research Foundation Itsuu Laboratory
- 当前专利权人： Research Foundation Itsuu Laboratory
- 当前专利权人地址： 28-10, Tamagawa 2-chome, Setagaya-ku Tokyo 158-0094 JP
- 代理机构： Polypatent
- 优先权： JP2007211650 20070815
- 国际公布： WO2009022721 20090219
- 主分类号： C07C233/65
- IPC分类号： C07C233/65 ; A61K31/381 ; A61K31/44 ; A61K31/455 ; A61P35/00 ; A61P43/00 ; C07C233/81 ; C07C311/21 ; C07D213/79 ; C07D213/81 ; C07D213/82 ; C07D333/38 ; C07D333/40
摘要：
A compound represented by the following general formula (I):
[wherein R 1 represents hydrogen atom or a C 1-6 alkyl group, A and B represent -(CH 2 ) 2 -, -(CH 2 ) 3 - or -(CH 2 ) 4 -, X represents -N(R 2 )-CO- (R 2 represents hydrogen atom or a C 1-6 alkyl group), -CO-N(R 3 )- (R 3 represents hydrogen atom or a C 1-6 alkyl group), -C(R 4 )=C(R 5 )- (R 4 and R 5 represent hydrogen atom or a C 1-6 alkyl group), or -N(R 6 )-SO 2 -(R 6 represents hydrogen atom or a C 1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has a retinoid action and is useful as an active ingredient of a medicament.
[wherein R 1 represents hydrogen atom or a C 1-6 alkyl group, A and B represent -(CH 2 ) 2 -, -(CH 2 ) 3 - or -(CH 2 ) 4 -, X represents -N(R 2 )-CO- (R 2 represents hydrogen atom or a C 1-6 alkyl group), -CO-N(R 3 )- (R 3 represents hydrogen atom or a C 1-6 alkyl group), -C(R 4 )=C(R 5 )- (R 4 and R 5 represent hydrogen atom or a C 1-6 alkyl group), or -N(R 6 )-SO 2 -(R 6 represents hydrogen atom or a C 1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has a retinoid action and is useful as an active ingredient of a medicament.
公开/授权文献:
- EP2189443B1 TRICYCLIC AMIDE COMPOUND 公开/授权日：2013-10-23
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C233/00 | 羧酸酰胺 |
| --------C07C233/01 | .羧酰胺基的碳原子连接在氢原子或非环碳原子上 |
| ----------C07C233/65 | ..羧酰胺基的氮原子连接在氢原子或未取代烃基的碳原子上 |