基本信息:
- 专利标题： METHOD OF USING PHYSIOLOGICAL MARKERS TO ESTIMATE CARDIOVASCULAR RISK
- 专利标题（中）：使用生理标志物对心血管的评价方法风险 -
- 申请号：EP02786705.0 申请日：2002-11-12
- 公开(公告)号：EP1451580A2 公开(公告)日：2004-09-01
- 发明人： EPSTEIN, Stephen, E. , ZHU, Juanhui
- 申请人： Medstar Research Institute
- 申请人地址： 108 Irving Street, N.W. Washington, DC 20010 US
- 专利权人： Medstar Research Institute
- 当前专利权人： Medstar Research Institute
- 当前专利权人地址： 108 Irving Street, N.W. Washington, DC 20010 US
- 代理机构： Maschio, Antonio, Dr.
- 优先权： US331189P 20011109; US340857P 20011219; US394245P 20020709
- 国际公布： WO2003039349 20030515
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
An individual's risk profile for developing a cardiovascular disorder or for experiencing a cardiovascular event is determined by 1) measuring levels of certain stress-evoked proteins including heat shock proteins (HSPs), cytokines, adhesion molecules, chemokines, and the like, or titers of the antibodies targeted to them, or 2) determining the number of seropositive responses to a group of pathogens that have been associated with the presence of atherosclerosis and/or clinical events related to atherosclerosis. The measured levels are compared with clinically derived standards that define the association of these markers with cardiovascular disease. These markers are independent of traditionally recognized risk factors.