发明公开
EP1086098A1 THIENYL SUBSTITUTED ACYLGUANIDINES AS INHIBITORS OF BONE RESORPTION AND VITRONECTIN RECEPTOR ANTAGONISTS
有权
基本信息:
- 专利标题： THIENYL SUBSTITUTED ACYLGUANIDINES AS INHIBITORS OF BONE RESORPTION AND VITRONECTIN RECEPTOR ANTAGONISTS
- 专利标题（中）：噻吩基取代酰基胍骨吸收抑制剂和玻连蛋白受体antagoniste
- 申请号：EP99924879.2 申请日：1999-05-05
- 公开(公告)号：EP1086098A1 公开(公告)日：2001-03-28
- 发明人： SCHEUNEMANN, Karl-Heinz , KNOLLE, Jochen , PEYMAN, Anuschirwan , WILL, David, William , CARNIATO, Denis , GOURVEST, Jean-Francois , GADEK, Thomas , MCDOWELL, Robert , BODARY, Sarah, Catherine , CUTHBERTSON, Robert, Andrew
- 申请人： Aventis Pharma Deutschland GmbH , Genentech, Inc.
- 申请人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 专利权人： Aventis Pharma Deutschland GmbH,Genentech, Inc.
- 当前专利权人： Aventis Pharma Deutschland GmbH,Genentech, Inc.
- 当前专利权人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 代理机构： Vieillefosse, Jean-Claude
- 优先权： EP98109077 19980519
- 国际公布： WO9959992 19991125
- 主分类号： C07D409/12
- IPC分类号： C07D409/12 ; A61K31/505 ; C07D333/38 ; A61K31/38 ; C07D333/40 ; C07D409/14
摘要：
The present invention relates to thienyl substituted acylguanidine derivatives, such as compounds of formula (I) in which R?1, R2, R4, R6¿, A, B and D have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of the present invention are valuable pharmaceutical active compounds. They are vitronectin receptor antagonists and inhibitors of bone resorption by osteoclasts. They are suitable, for example, for the therapy and prophylaxis of diseases which are caused at least partially by an undesired extent of bone resorption, for example of osteoporosis. The invention furthermore relates to processes for the preparation of thienyl substituted acylguanidines, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D409/00 | 杂环化合物，含两个或更多个杂环，至少有1个环有硫原子作为仅有的杂环原子 |
| --------C07D409/02 | .含有两个杂环 |
| ----------C07D409/12 | ..被含有杂原子的链作为键链连接的 |