EP0880518B1 A PROCESS OF MAKING 3-PHENYL-1-METHYLENEDIOXYPHENYL-INDANE-2-CARBOXYLIC ACID DERIVATIVES
失效
基本信息:
- 专利标题： A PROCESS OF MAKING 3-PHENYL-1-METHYLENEDIOXYPHENYL-INDANE-2-CARBOXYLIC ACID DERIVATIVES
- 专利标题（中）：制备3-苯基-1-甲二氧苯基 - 茚满-2-羧酸衍生物的方法
- 申请号：EP96940864.0 申请日：1996-11-08
- 公开(公告)号：EP0880518B1 公开(公告)日：2003-04-02
- 发明人： ANDEMICHAEL, Yemane, Woldeselassie , BAINE, Neil, Howard , CLARK, William, Morrow , KOWALSKI, Conrad, John , McGUIRE, Michael, Anthony , MILLS, Robert, John
- 申请人： SMITHKLINE BEECHAM CORPORATION
- 申请人地址： UW2220, 709 Swedeland Road, P.O. Box 1539 King of Prussia, PA 19406-0939 US
- 专利权人： SMITHKLINE BEECHAM CORPORATION
- 当前专利权人： SMITHKLINE BEECHAM CORPORATION
- 当前专利权人地址： UW2220, 709 Swedeland Road, P.O. Box 1539 King of Prussia, PA 19406-0939 US
- 代理机构： Blakey, Alison Jane
- 优先权： US6345P 19951108
- 国际公布： WO97017342 19970515
- 主分类号： C07D405/08
- IPC分类号： C07D405/08 ; C07D317/60 ; C07D317/52 ; C07D317/50 ; C07D233/38 ; C07D213/54 ; C07D213/30 ; C07D213/26 ; C07C309/65 ; C07C45/46 ; C07C45/71 ; C07C65/03 ; C07C65/21 ; C07C65/24 ; C07C305/26
摘要：
Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S, 2R, 3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S, 2R, 3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D405/00 | 杂环化合物，含有1个或多个以氧原子作为仅有的杂环原子的环，且含有1个或多个以氮原子作为仅有的杂环原子的环 |
| --------C07D405/02 | .含有两个杂环 |
| ----------C07D405/08 | ..被含脂环的碳链连接的 |