The invention discloses a curing method for reducing TSNAs in different varieties of flue-cured tobaccos by utilizing strains. The method comprises the following steps of harvesting fresh tobacco leaves, with the proper maturity, of the flue-cured tobaccos; classifying the harvested fresh tobacco leaves and then braiding the tobacco leaves into rods; preparing a bacterial solution with the OD600 value being 1 by using at least one strain in 05-101, J45 and J54, and then uniformly spraying the bacterial solution to the surface of the tobacco leaves which have been braided into the rods; loadingthe inoculated tobacco leaves which have been braided into the rods into a bulk curing barn; and curing the tobacco leaves which are loaded in a furnace, and obtaining the tobacco leaves with the lowTSNAs content through a yellowing stage, a color fixing stage and a stem drying stage. The special bacterial solution is inoculated to the fresh tobacco leaves which are about to be loaded in the furnace, and the stage changes of the environmental temperature and humidity in a drying chamber of the curing barn in the curing process are controlled according to the varieties of the tobacco leaves,so that the degradation of the TSNAs in the flue-cured tobaccos is promoted, the purpose of controlling the TSNAs content of the tobacco leaves to improve the quality of the flue-cured tobaccos is achieved, and the great significance is achieved for reducing the harm of the TSNAs in the tobaccos to the human health and the living environment.