The invention discloses a thread stitching type binding machine with multi-hole automatic threading and winding functions. The binding machine comprises a machine frame, a binding platform, a drillingdevice, a thread feeding device and an automatic thread-winding device, wherein the automatic thread-winding device comprises a thread supporting device and thread-winding devices which are arrangedon the two sides of the thread supporting device correspondingly, and the moving directions or the rotating directions of the two thread-winding devices located on the two sides of the same thread supporting device are opposite. According to the thread stitching type binding machine, the structure is simple, multi-hole automatic threading at the same time is realized, the binding speed is high, the binding efficiency is high, thread break is not prone to occurrence in the threading and thread-winding processes, the situation that a thread is loose or the thread is hooked is avoided, and the action is more stable, accurate and reliable in the whole binding process including threading and thread-winding.