基本信息:
- 专利标题： 螺缩酮多炔类化合物在制备抗外泵耐药金葡菌增敏药物中的用途
- 专利标题（英）：Application of spiroketal polyacetylene compounds in preparing sensitizing medicines for resisting efflux pump resistant staphylococcus aureus
- 申请号：CN201610901213.0 申请日：2016-10-14
- 公开(公告)号：CN107951878A 公开(公告)日：2018-04-24
- 发明人： 蓝江儿 , 李晓瑾 , 孙仲琳 , 顾娟 , 穆青
- 申请人： 复旦大学
- 申请人地址： 上海市邯郸路220号
- 专利权人： 复旦大学
- 当前专利权人： 复旦大学
- 当前专利权人地址： 上海市邯郸路220号
- 代理机构： 上海元一成知识产权代理事务所
- 代理人： 吴桂琴
- 主分类号： A61K31/35
- IPC分类号： A61K31/35 ; A61K31/431 ; A61P31/04 ; C07D493/10 ; C07D493/20
The invention belongs to the field of pharmacy, and relates to an application of spiroketal polyacetylene compounds in preparing sensitizing medicines for resisting efflux pump resistant staphylococcus aureus. Based upon results of bacteriostasis experiments, the spiroketal polyacetylene compounds, in the mode of a synergistic effect, can generate an antibacterial synergistic action on oxacillin;and especially, through combined use of the spiroketal polyacetylene compounds and the oxacillin, the minimum inhibitory concentration of the oxacillin can be obviously reduced, and a resistant staphylococcus aureus synergistic action can be taken on the oxacillin. The spiroketal polyacetylene compounds can be applied to the sensitizing medicines for resisting a multi-drug resistant staphylococcusaureus strain EMRSA-16 containing an mecA efflux pump drug resistance gene, as well as to a pharmaceutical composition which is prepared from the compounds and the oxacillin and has a resistant staphylococcus aureus resisting effect.
公开/授权文献:
- CN107951878B 螺缩酮多炔类化合物在制备抗外泵耐药金葡菌增敏药物中的用途 公开/授权日：2021-07-02
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/35 | ...有仅以1个氧作为环杂原子的六元环的 |