基本信息:
- 专利标题： 一种双糖基化苯并吩恶嗪类光敏剂及其制备方法和应用
- 申请号：CN201711118656.3 申请日：2017-11-13
- 公开(公告)号：CN107759642B 公开(公告)日：2020-06-05
- 发明人： 陈静 , 黄进华 , 康健 , 王臻 , 柳岸 , 宋相志 , 郭克华 , 马思祺 , 黄健 , 康丽阳 , 左成忻 , 杨盛波 , 黎以皓 , 李嘉豪 , 潘嘉瑶 , 汤归绍
- 申请人： 中南大学湘雅三医院
- 申请人地址： 湖南省长沙市河西岳麓区桐梓坡路138号
- 专利权人： 中南大学湘雅三医院
- 当前专利权人： 中南大学湘雅三医院
- 当前专利权人地址： 湖南省长沙市河西岳麓区桐梓坡路138号
- 代理机构： 长沙正奇专利事务所有限责任公司
- 代理人： 魏国先; 蒋尊龙
- 主分类号： C07H5/06
- IPC分类号： C07H5/06 ; C07H1/00 ; A61K41/00 ; A61P35/00
Disclosed are a diglycosylated benzophenoxazine photosensitizer and a preparation method and the use thereof. The present invention greatly improves the enriched concentration of the photosensitizer in tumor cells by taking full advantage of the enhanced uptake and enhanced glycolysis of carbohydrates by tumor cells and the glycosylation of a selenium-containing benzophenoxazine compound, thereby improving the targeting of a diglycosylated benzophenoxazine photosensitizer involved in the present invention in the treatment of cutaneous tumors and also significantly decreasing the toxicity and side effects of the photodynamic therapy. The present invention can efficiently and rapidly inhibit the proliferation of cells of cutaneous squamous cell carcinoma and essentially causing no damage to normal cells.
公开/授权文献:
- CN107759642A 一种双糖基化苯并吩恶嗪类光敏剂及其制备方法和应用 公开/授权日：2018-03-06