基本信息:
- 专利标题： 一种双糖基化苯并吩恶嗪类光敏剂及其制备方法和应用
- 专利标题（英）：Double-glycosylation benzophenoxazine photosensitizer as well as preparation method and application thereof
- 申请号：CN201711118656.3 申请日：2017-11-13
- 公开(公告)号：CN107759642A 公开(公告)日：2018-03-06
- 发明人： 陈静 , 黄进华 , 康健 , 王臻 , 柳岸 , 宋相志 , 郭克华 , 马思祺 , 黄健 , 康丽阳 , 左成忻 , 杨盛波 , 黎以皓 , 李嘉豪 , 潘嘉瑶 , 汤归绍
- 申请人： 中南大学湘雅三医院
- 申请人地址： 湖南省长沙市河西岳麓区桐梓坡路138号
- 专利权人： 中南大学湘雅三医院
- 当前专利权人： 中南大学湘雅三医院
- 当前专利权人地址： 湖南省长沙市河西岳麓区桐梓坡路138号
- 代理机构： 长沙正奇专利事务所有限责任公司
- 代理人： 魏国先; 蒋尊龙
- 主分类号： C07H5/06
- IPC分类号： C07H5/06 ; C07H1/00 ; A61K41/00 ; A61P35/00
The invention discloses a double-glycosylation benzophenoxazine photosensitizer as well as a preparation method and application thereof. By sufficient virtue of intake enhancement of tumor cells uponsugar compounds and glycolysis reaction enhancement, a selenium-containing benzophenoxazine compound is subjected to glycosylation, so that the enrichment concentration of a photosensitizer in tumor cells is greatly increased, the targeting property of the double-glycosylation benzophenoxazine photosensitizer disclosed by the invention in the skin tumor treatment process is improved, and the toxicand side effects of photodynamics therapy are greatly degraded. Proliferation of skin squamous carcinoma cells can be efficiently and rapidly inhibited, and normal cells are barely damaged.
公开/授权文献:
- CN107759642B 一种双糖基化苯并吩恶嗪类光敏剂及其制备方法和应用 公开/授权日：2020-06-05