The invention discloses a method for catalytic synthesis of 2,3,5-trimethylbenzoquinone. The method comprises the following steps: weighing trimethylphenol and Cu-ZSM-5 catalyst according to a mass ratio of 10:(1-3):1, adding a polar solvent and an oxidant, carrying out a reaction at 30-80 DEG C for 2-6 h, and filtering the obtained reaction product to obtain a filtrate which is the 2,3,5-trimethylbenzoquinone. The Cu-ZSM-5 catalyst having the stability of a traditional catalyst and the also having the characteristics of a micro-mesoporous material selectively catalytically oxidizes 2,3,5-trimethylphenol or 2,3,6-trimethylphenol into the 2,3,5-trimethylbenzoquinone in water, methanol, ethanol, a mixture solvent thereof or other green solvents under the action of H2O2, so the synthesis efficiency is high, and the Cu-ZSM-5 catalyst has no inactivation or collapsing phenomenon after being used multiple times. The method for synthesizing the 2,3,5-trimethylbenzoquinone is a new 2,3,5-trimethylbenzoquinone synthesis method having a high efficiency and an environmental protection property.