The invention relates to a gas-liquid replacement vacuumizing personnel protection cabin which comprises a vacuumizing cabin. A protection cabin body is arranged in the vacuumizing cabin. A vacuumizing cabin airtight door is arranged on one side of the vacuumizing cabin, and a protection cabin airtight door is arranged on one side of the protection cabin body. An air exhaust opening and a first protection gas filling opening are formed in the top of the protection cabin body, and a second protection gas filling opening and a vacuumizing cabin vacuumizing opening are formed in the vacuumizing cabin. A liquid injection and drainage pipeline tee joint is further included, the first end of the liquid injection and drainage pipeline tee joint is connected with a liquid injection opening, the second end of the liquid injection and drainage pipeline tee joint is connected with a liquid drainage opening, and the third end of the liquid injection and drainage pipeline tee joint is introduced into the protection cabin body. According to the gas-liquid replacement vacuumizing personnel protection cabin, the vacuum environment is isolated from the environment where working personnel are located, and the risks of the working personnel during vacuumizing are avoided. Gas injection and liquid drainage are achieved in the protection cabin body, and therefore air can be fast and effectively discharged, components in the air are prevented from being mixed with protection gas, the purity of the protection gas is greatly guaranteed, and protection period waste of the gas replacement link is reduced.