The invention relates to the technical field of stationeries and application of the stationeries, in particular to a mobile file cabinet with file boxes. The mobile file cabinet with the file boxes comprises a lower cabinet body and an upper cabinet body, wherein the lower cabinet body is fixed on a wall surface, and the upper cabinet body is used cooperatively with a moving mechanism for moving. Installation space layers are arranged on the two sides of the file cabinet and are used for mounting the moving mechanism; the moving mechanism comprises a horizontal movement assembly and an up-and-down movement assembly, wherein the horizontal movement assembly is used for enabling the upper cabinet body to move horizontally, and the up-and-down movement assembly is used for enabling the upper cabinet body to move up and down. The upper cabinet body and the lower cabinet body are composed of a plurality of small cabinet bodies, multiple pairs of mounting grooves are formed in the inner surfaces of the two side boards of each small cabinet body, and the mounting grooves are provided with dismountable mounting plates; the mounting plates are used for arranging the file boxes. According to the mobile file cabinet, files can be placed reasonably, so that files are placed and taken conveniently; the upper file cabinet can move up and down, files are easy to place and take, and potential safety hazard is small.