The invention discloses a production method of an anti-wear, anti-scratch and antistatic plastic decoration film. The production method comprises the following steps: (I) preparing an antistatic aid; (II) mixing the following raw materials in parts by weight: 30-70 parts of polyvinyl chloride, 10-20 parts of thermoplastic polyurethane plastic, 10-30 parts of vinyl chloride-acrylic ester copolymer resin, 0.5-3 parts of an aziridine crosslinking agent, 0.5-10 parts of an antistatic aid, 0.5-3 parts of a heat stabilizer, 0.5-2 parts of a plasticizer and 0.5-1 part of talc powder; and measuring one by one and mixing uniformly; (III) performing internal mixing, external mixing and extrusion and filtration; and (IV) calendering and cooling, and finally performing aftertreatment, namely trimming, rolling, inspecting and storing. The decoration film is applied to the cover decoration of furniture, floor, cupboard, internal wall integrated ceiling and the like. The decoration film prepared by the method has the advantages of scratch resistance, wear resistance, high light transmittance, strong tensile resistance, good extensibility and antistatic property.