The invention discloses a medicine powder stirring machine with a canning and opening sealing device. The medicine powder stirring machine comprises a stirring machine body, a machine frame and the canning and opening sealing device, wherein the stirring machine body is fixed on the machine frame; the canning and opening sealing device is arranged among four support feet; the stirring machine body comprises a machine case, a driving device and a transfer device; the machine case comprises a stirring barrel and a stirring head; the stirring head is fixed on the stirring barrel; the stirring barrel is a cylinder with an annular vacancy groove formed in the upper end surface; the driving device comprises a driving motor, a center rotating shaft, a center gear, a rotary pushing unit, an ascending and descending stirring block and a rotary turning device; the driving device is arranged on the stirring head; the transfer device comprises a rotary protection cover and a rotary gear ring, and is pivoted on the stirring head. The medicine powder stirring machine has the advantages that through the dual stirring of the rotary stirring device and the rotary turning device, the fast and full stirring can be realized; the canning and opening sealing device can achieve medicine powder canning and opening sealing effects; the scattering and the contamination of medicine powder are avoided.