The invention discloses a toxicity removing and swelling diminishing sea hare seafood soup base containing goldfussia psilostachys and a preparation method thereof. The toxicity removing and swelling diminishing sea hare seafood soup base is characterized by being made from, by weight, the goldfussia psilostachys, eranthemum pulchellum, Caesalpinia minax Hance, a vaiante spleenwort herb, pheropsophus jessoensis, wintercreeper, spermacoce latifolia, cottonrose hibiscus leaves, sea hare meat powder, undaria pinnatifida granules, dried laver, diced onions, sliced green onion, cassava starch, salt, pepper powder, ginger and star anise and is made through the processes of cleaning, drying, mixing, impurity removal, sterilization and bagging and the like. The toxicity removing and swelling diminishing sea hare seafood soup base has a delicious taste, is convenient to store and has the toxicity removing and swelling diminishing effects, and the preparation process is simpler and more hygienic.